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Abstract: Leprosy or Hansen's disease is caused by an obligate intracellular pathogen i.e. Leprosy is a granulomatous disease of peripheral nerves and mucosa of the upper respiratory tract. Bowers KJ, Chow E, Xu H, Dror RO, Eastwood MP, Gregersen BA, Klepeis JL, Kolossvary I, Moraes MA, Sacerdoti FD, Salmon JK, Shan Y, Shaw DE (2006) Scalable Algorithms for Molecular Dynamics Simulations on Commodity Clusters. Abstract: For dynamic optimization problems, the aim of an effective optimization algorithm is both to find the optimal solutions and to track the optima over time.

Ki "Economic Load Dispatch: A New Hybrid Particle Swarm Optimization Approach"sept.11 2007.

Key words: docking, homology modeling, leprosy, M.leprae, molecular, molecular dynamics, ramachandran plot.

Halgamuge "Self-Organizing Hierarchical Particle Swarm Optimizer With Time Varying Acceleration Coefficients" IEEE Trans. A well organized research comprising of analogue based drug design and molecular dynamics plays a major role in obtaining the lead molecules. Black PN, Di Russo CC, Metzger AK, Heimert TL (1992): Cloning, sequencing, and expression of the fad D gene of Escherichia coli encoding Acyl coenzyme A Synthetase.

The organism requires minimal set of functional genes for its survival. Bateman A, Birney E, Cerruti L (2002).‖The Pfam Protein Families Database‖. Two kinds of improved evolution rules are proposed to replace the rule in regular cellular genetic algorithm, in which null cells are considered to the foods of individuals in population and the maximum of living individuals in cellular space is limited by their food.

This infectious disease results in Leprosy reactions that cause irreversible nerve damage and disabilities. Black PN, Zhang Q, Weimar JD, Di Russo CC (1997) Mutational analysis of a fatty Acyl-coenzyme A Synthetase signature motif identifies seven amino acid residues that modulate fatty acid substrate specificity. In: Proceedings of the ACM/IEEE Conference on Supercomputing (SC06), Nov 11–17, Florida. Chemotherapy of leprosy for control programs- report of WHO study (2004). In this paper, we advanced two kinds of cellular genetic algorithms inspired by the density dependence scheme in ecological system to solving dynamic optimization problems.

However, no computer can process the near infinite number of atoms in objects, so instead we model 'finite' groups of them.

In the real world, everything that occurs results from the interaction between atoms (and sub-particles of those atoms). If we were to simulate the world in a computer, we would have to simulate this interaction based on the simple laws of physics. Domenico Prattichizzo,, and Antonio Bicchi,"Dynamic "Analysis of Mobility and Graspability of General Manipulation Systems" IEEE transactions on robotics and automation, vol. This paper presents a review of PSO application in Economic Load Dispatch problems.

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